From single-cell sequencing data analysis to MR analysis outcomes, genes such as RNASET2, ANXA4, and TMBIM1 exhibited a positive causal effect on CRC risk, whereas RAB11A, IER3, SCARB2, ATF3, and CXCL8 demonstrated a negative causal effect. Here, CXCL8 is linked to colorectal carcinoma.