Additionally, other types of genes also demonstrated significant “switch” effects during CRC epithelial cell development (Figure 7A), such as surface protein molecules SNRPD2, SLC12A2, XRCC6, and CEACAM1, as well as potential transcription factors ETS1, PRDM1, EGR1, and MYB, with more information on related genes available in Figure 7A. Due to the high explanatory power and lowest p-value and FDR values of IER3, it is considered the key “switch” gene in this analysis. This evidence concerns the gene EGR1 and colorectal carcinoma.