Subsequent MR analysis using the IVW method indicated positive correlations between RNASET2, ANXA4, and TMBIM1 and CRC risk, while RAB11A, IER3, SCARB2, ATF3, and CXCL8 were negatively correlated with CRC risk (Figure 6A). Here, TMBIM1 is linked to colorectal carcinoma.