This chemokine system, like MCH and HCRT, is stimulated in rodents by prenatal alcohol exposure, and it is positively linked to the overconsumption of rewarding substances like alcohol and a high-fat diet [121,122,123,124], to cocaine-induced locomotor sensitization [125] and to behaviors such as anxiety and locomotor activity [126,127,128]. The gene discussed is HCRT; the disease is Anxiety.