Like MCH, this chemokine system is closely related to reward pathways, with CCL2 shown to stimulate striatal DA release [120], and it is also positively linked to the overconsumption of rewarding substances like alcohol and a high-fat diet [121,122,123,124], to cocaine-induced locomotor sensitization [125] and to behaviors such as anxiety and locomotor activity [126,127,128]. This evidence concerns the gene PMCH and Anxiety.