This is shown by evidence that MCH activity and chronic MCH treatment or overexpression increase the preference for highly palatable food and the susceptibility toward greater high-fat feeding and obesity [14,15], and a deficiency of MCH or antagonism of the MCHR1 receptor reduces the motivation to consume a fat-rich diet [14,16]. The gene discussed is PMCH; the disease is obesity due to melanocortin 4 receptor deficiency.