HDAC1 and colonic neoplasm: There is experimental evidence that silencing p300 reduces histone lactylation in the HCT116 human colon cancer cell line (HCT116) and Human Embryonic Kidney 293T (HEK293T) cells, while Sirtuin 1-3 (SIRT1-3) and Histone Deacetylase 1-3 (HDAC1-3) serve as primary lactylation erasers, with HDAC1 and HDAC3 exhibiting robust activity in hydrolyzing both L-lactate and D-lactate modifications [5,26].