Crucially, METTL15 knockout models demonstrate the concomitant elevation of lactate secretion and histone lactylation levels (H4K12la and H3K91la), positioning METTL15 as a promising regulatory node for investigating the crosstalk between mitochondrial metabolism and histone lactylation reprogramming during sepsis [118]. The gene discussed is METTL15; the disease is Sepsis.