Systemic lupus erythematosus patients exhibit mtDNA-release-induced metabolic reprogramming, characterized by the glycolytic upregulation of monocytes and macrophages, mitochondrial impairment, and lactate-driven cyclic guanosine monophosphate–adenosine monophosphate synthase (cGAS) lactylation that activates cyclic guanosine monophosphate–adenosine monophosphate synthase stimulator of interferon genes—Interferon alpha 1 (cGAS-STING-IFN1) signaling that aggravates inflammation [41,42,43]. The gene discussed is CGAS; the disease is systemic lupus erythematosus.