CNOT7 overexpression in HCC tissues has also been found to be associated with decreased STAT1 expression, which normally forms a dimer with p65, a distinct protein of the NF-κB family of dimeric transcription factors, inhibiting it from being translocated to the nucleus to promote TGF-β1 transcription [28]. This evidence concerns the gene NFKB1 and hepatocellular carcinoma.