The notable exception of this trend was observed in COAD, READ, and STAD, where CXCR3 displayed a positive correlation with PEBP1/STK11 expression, highlighting the complex and context-dependent interplay between PEBP1/STK11 and chemokine-mediated immune regulation in the tumor microenvironment. Here, CXCR3 is linked to colon adenocarcinoma.