Our analysis revealed a widespread negative correlation between the co-expression of these genes and the expression of genes encoding immune checkpoint molecules, such as CD274, PDCD1LG2, PDCD1, CTLA4, TIGIT, and CD244, across multiple cancer types, including gastrointestinal, reproductive, nervous, respiratory, ocular, and hematopoietic cancers. The gene discussed is PDCD1LG2; the disease is hematopoietic and lymphoid cell neoplasm.