TLR4 and bacterial infectious disease with sepsis: In our study, several key immunoregulatory genes related to bacterial infection were upregulated, including ZNFR1, involved in TLR4 signaling induced by Gram-negative bacteria; BACH, involved in the adaptive immune response; and CXCL1, a chemokine that promotes neutrophil recruitment and has recently been shown to increase earlier than CRP in children with cancer and bacteremia.