The ADGRE1 and IFI44L 2-gene signature identified 14 (52%) of 27 episodes with bacteremia on day 1 as a bacterial infection (sensitivity 0.52, 95% CI 0.32–0.71) and 39 (60%) of 65 episodes without bacterial infection and low CRP as not having bacterial infections (specificity 0.60, 95% CI 0.47–0.72), using the proposed threshold of 0 (Figure 4). This evidence concerns the gene CRP and bacterial infectious disease.