Among this, a specific circRNA was found to regulate glycolysis in breast cancer cells via miR-1252-5p-mediated regulation of PFKFB2 (6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 2) expression, emphasizing the metabolic reprogramming potential of EVs from cancer cells [191]. Here, PFKFB2 is linked to breast cancer.