IFNA1 and systemic lupus erythematosus: The overexpression of TLR7 and TLR8, encoding endosomal pattern recognition receptors, enhances IFN-I signaling and proinflammatory cytokine production, particularly in pDCs, driving upregulation of IFN-stimulated genes and predisposing females to SLE and related autoimmune diseases [47,125,133].