Estrogen suppresses anti-inflammatory miRs (e.g., let-7e, miR-98, miR-145, miR-26a) and upregulates proinflammatory ones (e.g., miR-10b), promoting IFN-I signaling, AID expression, and autoantibody production—key features in SLE pathogenesis. Here, AICDA is linked to systemic lupus erythematosus.