IL6 and systemic lupus erythematosus: In lupus, high-fat and high-sugar diets that lead to obesity may worsen SLE outcomes through proinflammatory adipokines (e.g., IL-6, TNFα), while fiber-rich, low-carbohydrate diet or Mediterranean diets rich in antioxidants and polyunsaturated fats may attenuate systemic inflammation and disease activity [1].