This specialized subset—CD177+ neutrophils—exhibits enhanced microbial killing through ROS generation, AMP release, and NETosis, while limiting pro-inflammatory cytokine output (IL-6, IL-17A, IFNγ) and producing reparative mediators (IL-22, TGFβ), thus supporting tissue healing in IBD [59]. The gene discussed is IL22; the disease is irritable bowel syndrome.