GBM exhibits notably higher LDLR expression compared to low-grade astrocytoma and high-grade astrocytoma epidermal growth factor receptor variant III (EGFRvIII), a common epidermal growth factor receptor (EGFR) mutation in the mesenchymal GBM subtype, has been shown to significantly upregulate LRP1 expression, suggesting a correlation between elevated LRP1 levels and the poor prognosis associated with these tumors [359]. This evidence concerns the gene LDLR and astrocytoma (excluding glioblastoma).