The most common asthma variant in children, T2-high asthma, is characterized by atopy, eosinophilic inflammation, elevated Th2 cytokines (IL-4, IL-5, and IL-13), and leukocyte recruitment driven by CD4 + T-cells, mast cells, and eosinophils [9,10,11]. The gene discussed is IL4; the disease is asthma.