A Mann–Whitney test showed a significant difference between the group of patients with SLE and controls, both in terms of PIK3AP1 gene expression levels (p-value = 0.04; mean “HD” = 1.1, and mean “SLE” = 1.6) and IFN score (p-value < 0.0001; mean “HD” = 1.3, and mean “SLE” = 26.3) (Figure 1A,B). Here, PIK3AP1 is linked to systemic lupus erythematosus.