Interestingly, the high mammosphere formation capacity of M13HS-2 and M13HS-8 tumor hybrids was almost completely eliminated in their Snail-KO counterparts (M13HS-2: 70 ± 16 vs. M13HS-2 Snail-KO: 4 ± 1; M13HS-8: 19 ± 4 vs. M13HS-8 Snail-KO: 6 ± 1; Figure 3A). Here, SNAI1 is linked to neoplasm.