JAK2 and oral cavity squamous cell carcinoma: P. gingivalis also appears to stimulate IL-6 expression via the janus kinase 2/glycogen synthase kinase 3 beta/signal transducer and activator of transcription 3 (JAK2/GSK3-β/STAT3) signaling pathway, which is linked to carcinogenesis and the development of oral squamous cell carcinoma [127].