AGT and hypertensive disorder: We included 12 animal studies investigating various hypertensive phenotypes: angiotensin-II (Ang-II)-induced HTN (n = 3), programmed developmental HTN (n = 2), hypoxia-induced HTN (n = 2), metabolic HTN (n = 2), salt-sensitive HTN (n = 2), and spontaneous HTN (n = 1) (Table 2) [29,30,31,32,33,34,35,36,37,38,39,40].