Therefore, the aim of this systematic review and meta-analysis was to evaluate the impacts of vitamin D on both glycemic control and inflammation in adults with T2DM focusing on key biomarkers including fasting plasma glucose (FPG), insulin levels, HOMA-IR, HOMA-B, HbA1c, TNF-alpha, and Hs-CRP. Here, INS is linked to type 2 diabetes mellitus.