MAPT and Alzheimer disease: Curcumin could protect neuron-like PC12 rat cells and umbilical endothelial cells from Aβ damage by inhibiting oxidative damage and excessive hyperphosphorylation of tau protein [25], promote the uptake of Aβ by macrophages of AD patients [26], and dose-dependently reduce the formation and extension of fibroblasts, while disrupting the stability of pre-formed Aβ fibrils [27,28,29].