Although EDS is a symptom rather than a distinct sleep disorder, it can often result from underlying sleep disorders, such as obstructive sleep apnea, sleep disturbances, short or long sleep duration, or circadian rhythms, which are themselves associated with hormonal dysregulation—such as increased ghrelin and reduced leptin levels—that promote weight gain [20,21,22]. This evidence concerns the gene GHRL and Ehlers-Danlos syndrome.