Some of these key factors are not limited to, but include a blunted Akt phosphorylation response, dysregulation of PI3K/Akt/mTOR signaling, increased presence of proinflammatory cytokines, increases in oxidative stress associated with senescence, altered enzymatic functioning, and obesity [36,44,45]. Here, AKT1 is linked to obesity due to melanocortin 4 receptor deficiency.