When we use UPF1 to define the high and low consumption of UPF, the unadjusted model showed that participants with depression have a higher likelihood of having diabetes (OR: 1.515, 95% CI: 1.408 to 1.629), while those with higher UPF intake were less likely to have diabetes (OR: 0.370, 95% CI: 0.352 to 0.389), this fact is consistent when using the UPF2 for definition (OR: 1.529, 95% CI: 1.422 to 1.643 with depression, and OR: 0.371, 95% CI: 0.309 to 0.446 with UPF). The gene discussed is UPF2; the disease is diabetes mellitus.