When defined by UPF1, the association between depression and diabetes in the interactive model was no longer significant (OR: 1.035, 95% CI: 0.836 to 1.281), while the strength and significance of this association in interactive model was slightly reduced when defined by UPF2 (OR: 1.209, 95% CI: 1.021 to 1.432), which is expected due to the inclusion of interaction terms. This evidence concerns the gene UPF1 and major depressive disorder.