Additionally, P. gingivalis seems to promote IL-6 expression through the janus kinase 2/glycogen synthase kinase 3 beta/signal transducer and activator of transcription 3 (JAK2/GSK3-β/STAT3) pathway, which is associated with carcinogenesis and oral squamous cell carcinoma [132]. This evidence concerns the gene STAT3 and oral cavity squamous cell carcinoma.