Visceral adipose tissue is an active endocrine organ that secretes proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and C-reactive protein (CRP), which contribute to systemic low-grade inflammation, a hallmark of obesity-related metabolic dysfunction [39]. This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.