Inflammatory markers, including interleukin-6 (IL-6), tumor necrosis-α (TNF-α), C-reactive protein (CRP), and adipokines, such as leptin and adiponectin, play central roles in obesity-induced inflammation [3,6,7], with weight loss ameliorating these effects and decreasing obesity-related adverse health outcomes [8,9,10]. This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.