Genes related to these pathways, including fructose-bisphosphate aldolase (ALOD), sucrose synthase (SUS), diphosphate-dependent phosphofructokinase (PFP), and 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (PGAM), were predominantly down-regulated in CD treatment but up-regulated in AD (Figure 9). The gene discussed is PRF1; the disease is Alzheimer disease.