During skin pathophysiological processes where inflammation and oxidative stress predominate, triggered by UV exposure, infections, pollution, aging, or comorbidities, stromal and immune cells release enzymes that degrade the extracellular matrix (ECM), such as matrix metalloproteinases (e.g., collagenases), serine proteases (e.g., neutrophil elastase), and hyaluronidases. The gene discussed is ELANE; the disease is infection.