They also secrete chemokines such as C-X-C Motif Chemokine Receptor 4 (CXCR4), CCL2, and CCL5, as well as VEGF and S100 calcium-binding proteins A8/A9 (S100A8/A9), which facilitate tumor progression, angiogenesis, and the recruitment of other immunosuppressive cells [23,29,41,42]. The gene discussed is VEGFA; the disease is neoplasm.