TNF and neoplasm: Such tumor-promoting neutrophils, often classified as “N2” tumor-associated neutrophils (TANs), further support cancer progression by forming neutrophil extracellular traps (NETs), secreting pro-inflammatory cytokines such as IL-17 and tumor necrosis factor alpha (TNF-α), remodeling ECM components, and inhibiting T-cell-mediated immunity [13,14,15].