Cisplatin-induced ferroptosis in tumor cells triggers the release of CXCL1/2 and DAMPs, recruiting neutrophils and polarizing TANs to N1 characterized by the upregulation of TNF-α, granzyme B, and NE. N1 TANs enhance T cell infiltration, CD4+ T cell differentiation, and CD8+ T cell activation and migration. Here, CD4 is linked to neoplasm.