TGFB1 and neoplasm: In contrast, N2 TANs possess regular or circular nuclei and are induced by a wide array of tumor- and stroma-derived factors, including TGF-β, IL-6, IL-17, CXCL2, prostaglandin E2 (PGE2), granulocyte colony-stimulating factor (G-CSF), GM-CSF, and hyaluronic acid (HA) fragments [23,29,36,37,38,39,40].