IRS1 and neoplasm: TANs further contribute to tumor proliferation through the secretion of PGE2 in a zebrafish RAS-driven tumor model [60] and through NE-mediated degradation of insulin receptor substrate-1 (IRS-1), which enhances interactions between phosphatidylinositol 3-kinase (PI3K) and the potent mitogen platelet-derived growth factor receptor (PDGFR), promoting tumor cell proliferation [59].