Meanwhile, Skara et al. (2023) [88] showed that methylation of the CpG1 region of the CAV1 gene in seminal plasma cfDNA was higher in BPH patients than in PC patients, with a diagnostic accuracy (AUC 0.63) exceeding that of PSA (AUC 0.52). This evidence concerns the gene KLK3 and benign prostatic hyperplasia.