EIF4EBP1 and head and neck squamous cell carcinoma: In FA− deficient HNSCC cells, we observed a dose-dependent sensitization to rapamycin (Figure 5), likely influenced by the differential sensitivity of downstream targets—S6 is dephosphorylated at nanomolar concentrations, whereas 4E-BP1 is dephosphorylated at micromolar concentrations [68,69], which may explain more pronounced effects at higher doses.