CD8A and breast neoplasm: Across independent deconvolution methods (Supplementary Figures S5 and S6), the PanRibo-515 score consistently correlates with (i) diminished cytotoxic/effector cells—CD8+ T, NK, γδ-T and M1 macrophages—most sharply in KIRC, LUAD/LUSC and BRCA; (ii) enrichment of suppressive myeloid elements (M2 macrophages, neutrophils, MDSC-like and non-classical monocytes), especially in GI, lung and breast tumors; and (iii) increased fibroblast, endothelial and overall stromal signatures that fortify an immune-excluding micro-environment.