Furthermore, CENPN, which recognises the N-terminal region of the CENPA nucleosome and binds to CENPL to form a mitophagy-associated network [73], has also been shown to supress autophagy and increase paclitaxel resistance in NPC by inhibiting the CREB-VAMP8 signalling axis. This evidence concerns the gene CENPN and nasopharyngeal carcinoma.