Using these novel co-culture models, it was shown that AML cells could be eliminated by activated macrophages in co-cultures, by inhibiting the ‘don’t eat me signal’ CD47 and increasing the ‘eat me signal’ CRT on the surface of AML cells to flag them for elimination by macrophages in vitro [51], which may help in characterizing new immunomodulatory therapies that may be useful for treating the disease. The gene discussed is CD47; the disease is acute myeloid leukemia.