PVR and glioblastoma: Poliovirus recombinant Sabin-rhinovirus IRES (PVSRIPO) is an engineered oncolytic poliovirus derived from the Sabin type 1 strain, modified with a human rhinovirus type 2 IRES to reduce neurovirulence while preserving its ability to target tumors overexpressing CD155, a receptor highly expressed in GBM [160].