SOAT1 and Merkel cell skin cancer: Additionally, IFN-γ-mediated activation of Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) pathways enhances the recruitment of immune cells (e.g., NK cells and macrophages) to the TME [48], which may synergize with ICIs to overcome resistance in refractory MCC.