In the comparisons of this study, it is relevant to underline that, even if the study was retrospective, the endoscopists were blinded to the patient’s history (including previous radiological examinations) and that CH-EUS was more accurate than Ki-67% and tumor size (>2 cm) for predicting aggressiveness in G1/G2 tumors. This evidence concerns the gene MKI67 and neoplasm.