To evaluate whether ILs could impact OSCC cell phenotype, we exposed SCC-25 cells (a human cell line derived from a tongue SCC) and Detroit cells (a human cell line derived from an oropharyngeal SCC) for 7 days to combined IL-1 beta, IL-6, and IL-8 (IL-SCC-25 cells and IL-Detroit cells), as performed on NOKs (Supplementary Figure S3a). Here, IL1B is linked to oral cavity neoplasm.