Analogous to the observation that colorectal cancer (CRC) cell-derived exosomal B7-H3 can be internalized by human umbilical vein endothelial cells (HUVECs), leading to activation of the AKT/mTOR/VEGFA signaling axis and enhanced migratory and angiogenic potential, it is plausible that melanoma-derived exosomes may similarly confer new functional properties to recipient cells. The gene discussed is VEGFA; the disease is colorectal cancer.