The frequency of CD56bright NK cells expressing the activating receptor CRACC was increased, while NKp30-positive CD56bright were decreased in STS patients (100%, IQR: 99–100, N = 6; 84%, IQR: 70–95, N = 12; respectively) compared with CTRL (79%, IQR: 73–84, N = 11, p = 0.0002; 94%, IQR: 89–98, N = 21, p = 0.03; respectively). Here, NCR3 is linked to telomere syndrome.