INS and cancer: Our KEGG pathway enrichment analysis revealed that the DE miRNAs were involved in key cancer-related pathways, such as cell cycle, proteoglycans in cancer, focal adhesions, Hippo signaling, p53 signaling, TGF-β signaling, insulin signaling and PI3K-Akt signaling, many of which participate in the regulation of DNA damage repair [22,23,48,49], one of the primary mechanisms of resistance against cisplatin-induced cytotoxicity [50].