Collectively, our six-miRNA signature not only incorporates miRNAs with suggested prognostic significance across NSCLC tissue samples but also highlights their convergence on DNA damage repair-related signaling pathways, such as p53, Hippo, TGF-β and PI3K-Akt, offering a broader mechanistic insight into chemoresistance. Here, PIK3CA is linked to non-small cell lung carcinoma.