Future research involving larger pediatric populations, expanded longitudinal assessment, and integrative analyses that correlate serum biomarker concentrations with their tissue-specific protein expression profiles would be instrumental in further validating and clarifying the prognostic role of TMPRSS6, NEO1, and sHJV in pediatric acute leukemia, as well as in elucidating their biological contributions to iron dysregulation observed in these patients. This evidence concerns the gene TMPRSS6 and acute leukemia.