Moreover, it has been shown that breast-cancer-derived Wnt3a (a member of Wnt gene family, clustered on human chromosome 1q42) can also generate adipocyte-derived fibroblasts (ADFs) through differentiation of adipocytes that express high levels of a CAF-specific marker called fibroblast specific protein 1 (FSP-1) through a highly conserved signal transduction pathway called the Wnt/β-catenin pathway [10,46]. The gene discussed is S100A4; the disease is breast cancer.