According to the (tissue-based) Cancer Genome Atlas (TCGA) project, TP53 heterozygous deletions are moderately common in PCa, occurring in approximately one third of cases, but significantly less frequently than in other common solid tumors such as breast adenocarcinoma (51%) or rectal adenocarcinoma (64%) [154]. This evidence concerns the gene TP53 and rectum adenocarcinoma.