Mechanistically, overexpression of miR-375 was described in PCa cell lines to be associated with proliferation and metastasis; additionally, it is linked with resistance to both ENZ (by silencing the expression of PTPN4, an inactivator of STAT3) and docetaxel (by silencing SEC23A and YAP1) [159,160]. This evidence concerns the gene STAT3 and posterior cortical atrophy.