One study demonstrated that GNF-7 inhibited the kinases ACK1 (activated Cdc42-associated kinase; TNK2) and GCK (germinal center kinase; MAP4K2) in an N-Ras mutant leukemia model, while another established that necroptosis in an acute kidney injury model could be prevented by GNF-7 via binding to RIPK1/3 (receptor interacting serine/threonine kinase 1/3) [39,40]. Here, TNK2 is linked to leukemia.