LEF1 and acute lymphoblastic leukemia: More specifically, PKF115-584, which disrupts the β-catenin and LEF1 complex, prevented and even partially reversed leukemogenesis by inducing apoptosis and decreasing proliferation in human T-ALL cells (RPMI8402, HPB-ALL, JURKAT, CCRF-CEM) [108] and inhibited survival of T-ALL leukemic cells in vivo.