Moreover, it has been shown that Wnt proteins (Wnt2b, Wnt5a, Wnt10b, and Wnt16b) enhance the proliferation of B-ALL cell lines [57] and that Wnt pathway signaling is necessary for supporting the survival of B-ALL LSCs in conjunction with bone marrow stromal cells [95]. The gene discussed is WNT2B; the disease is precursor B-cell acute lymphoblastic leukemia.