HNF4A and acute lymphoblastic leukemia: In a complimentary experiment, genetic inactivation of the Wnt pathway by blocking β-catenin using a lentivirus encoding dominant negative TCF (dnTCF) lacking the N-terminal β-catenin binding domain (dnTCF) into human T-ALL cell lines (HPBALL and RPMI 8402), substantially reduced the frequency of LICs and led to survival prolongation in xenografted T-ALL in mice [83].