In colorectal cancer, Change et al. [48] have shown that miR-218-5p can be expressed by Parvimonas micra in the gut microbiome, leading to downregulation of protein tyrosine phosphatase receptor R (PTPRR) and causing tumor progression, showing that microenvironment-derived miR-218-5p can also affect cancer development. The gene discussed is PTPRR; the disease is colorectal cancer.