AFP and hepatocellular carcinoma: Differences between FLC and conventional hepatocellular carcinoma (cHCC) are evident in their biological underpinnings, patterns of locoregional and distant spread at diagnosis, and overall clinical course [9,11,12,13], e.g., absence of elevated α-fetoprotein (AFP) levels [14,15] and lack of underlying liver disease [16] often delay diagnosis of FLC, and characteristic fusions between PRKACA and DNAJB1 were identified as oncogenic driver in FLC, but not in cHCC [12,17].