Three of the seventeen (17.6%) frameshift mutations identified in AML patients #1 and #6 (Figure 2) are potentially pathogenic, as they likely lead to truncations in the C-terminus of BCOR (R1532fs) and BCORL1 (V1687fs, E1655fs) proteins, affecting the binding of BCOR with the PRC1.1 complex through its PUFD domain at the C-terminal end [6,31]. Here, BCOR is linked to acute myeloid leukemia.