L1 cell adhesion molecule (L1CAM) is a transmembrane glycoprotein, physiologically expressed in the basolateral membrane of principal cells in the renal collecting system and distal tubules Among renal tumors, its expression has been consistently reported in LOT, while it is typically absent in oncocytomas, E-chRCC, and EVT [5]. The gene discussed is L1CAM; the disease is oncocytic adenoma.