L1 cell adhesion molecule (L1CAM) is a transmembrane glycoprotein, physiologically expressed in the basolateral membrane of principal cells in the renal collecting system and distal tubules Among renal tumors, its expression has been consistently reported in LOT, while it is typically absent in oncocytomas, E-chRCC, and EVT [5]. Here, L1CAM is linked to chromophobe renal cell carcinoma.