This study therefore utilized multiparametric PET/MRI to spatially resolve distinct intratumoral habitats in a preclinical HER2+ breast cancer model, integrating imaging parameters from clinically- and biologically relevant quantitative imaging approaches (DCE-MRI, DW-MRI, and [18F]FDG- and [18F]FLT-PET). The gene discussed is ERBB2; the disease is breast carcinoma.