Additionally, Yang et al. fed channel catfish with polysaccharides from A. bisporus and observed an enhancement in the expression of immune-related factors (IL-1β, Hsp70, and IgM); when the feeding content of A. bisporus polysaccharides exceeded 125 mg/kg, the protection rate against Yersinia ruckeri bacterial infection in fish exceeded 60% [41]. The gene discussed is CD40LG; the disease is bacterial infectious disease.