In addition, the presence of QTLs related to health and immune responses (e.g., interleukin-4 level and bovine tuberculosis susceptibility) further connects selection signatures to broader physiological adaptation, which could correspond to some pathways such as cell–cell junction and calcium ion binding, supported by genes like LYN [46] and INPP4B [47,48]. This evidence concerns the gene IL4 and Tuberculosis, Bovine.